Resolving blood clots
نویسندگان
چکیده
منابع مشابه
Invadopodia formation in blood clots
Blood clotting specifically supports the metastatic dissemination of malignant cells to the lung. We have recently demonstrated that 2 tumor types that are prone to form lung metastases, renal cell carcinoma and soft tissue sarcoma, share specific adhesive mechanisms that support the invasion and colonization of blood clots in the pulmonary vasculature.
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OBJECTIVE Obstructive thrombi or thrombotic emboli are the pathogenic basis of ischemic stroke. In vitro blood clots and in vivo thrombi can undergo platelet-driven contraction (retraction), resulting in volume shrinkage. Clot contraction can potentially reduce vessel occlusion and improve blood flow past emboli or thrombi. The aim of this work was to examine a potential pathogenic role of clot...
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Adenovirus type 5 was isolated from blood clots from 27 of 30 sporadic cases of infectious hepatitis. Only one isolation of virus, also adenovirus 5, was made from blood clots from 70 persons with no known contact with infectious hepatitis.
متن کاملAn apparatus for measuring the tensile strength of blood clots.
An apparatus is described which uses the principle of the ballistic pendulum to measure the tensile strength of blood clots formed in special cuvettes. The method appears to have a reproducibility which would allow a study to be made of the factors influencing clot strength. A brief survey of the findings with normal blood and with blood from cases of thrombosis and haemophilia shows significan...
متن کاملA model for the formation and lysis of blood clots.
Both biochemical and mechanical factors have to be taken into account if a meaningful model for the formation, growth, and lysis of clots in flowing blood is to be developed. Most models that are currently in use neglect one or the other of these factors. We have previously reported a model [J Theoret Med 2003;5:183-218] that we believe is a step in this direction, incorporating many of the cru...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2011
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd3523